Circulating exosome characterization in patients with MM. (A) Distribution of mappable small RNAs by next-generation sequencing in circulating exosomes from 10 patients with MM and 5 healthy donors. (B) qRT-PCR of circulating exosomal miRNAs in 10 patients with MM and 5 healthy donors. Box plots represent the medians and standard deviations of the normalized expression levels of 22 miRNAs. lincRNA, long intergenic noncoding RNA; misc_RNA, miscellaneous other RNA; mt-rRNA, ribosomal RNA located in mitochondrial genome; mt-tRNA, transfer RNA located in mitochondrial genome; rRNA, ribosomal RNA; snoRNA, small nucleolar RNA; snRNA, small nuclear RNA.