Accuracy of plasma cfDNA genotyping vs tumor gDNA genotyping. The mutation abundance in plasma cfDNA vs the mutation abundance in tumor gDNA is comparatively represented in the scatter plot for each variant identified in the training (A) and validation (C) DLBCL cases. ROC analysis illustrates the performance of plasma cfDNA genotyping in detecting biopsy-confirmed tumor variants according to the variant allele frequency of mutations in tumor gDNA in the training (B) and validation (D) DLBCL cases. The bar graph shows the allele frequency in tumor gDNA of the variants that were discovered in plasma cfDNA (red bars) or missed in plasma cfDNA (gray bars). The dash line tracks the 20% variant allele frequency threshold.