AML blasts enhance lipolysis of adipocytes in an FABP4-dependent manner, resulting in an enhanced secretion of free fatty acids that drive β-oxidation in AML cells and facilitate enhanced survival, proliferation, and transformation potential. Acetyl-CoA, acetyl coenzyme A; CPT1A, carnitine palmitoyltransferase 1A; MAT, marrow adipose tissue; lipase-p, phosphorylated lipase; TCA, tricarboxylic acid cycle.