OS by time periods and study cohorts. (A) All patients (2000-2004 vs 2010-2014, P < .001; 2000-2004 vs 2005-2009, P < .001; 2005-2009 vs 2010-2014, P = .001). (B) ASCT-treated patients (2000-2004 vs 2010-2014, P < .001; 2000-2004 vs 2005-2009, P = .07; 2005-2009 vs 2010-2014, P < .001). (C) Standard treatment patients (2000-2004 vs 2010-2014, P < .001; 2000-2004 vs 2005-2009, P < .001; 2005-2009 vs 2010-2014, P = .33). (D) Landmark analysis at 6 months among standard treatment patients (2000-2004 vs 2010-2014, P < .001; 2000-2004 vs 2005-2009, P < .001; 2005-2009 vs 2010-2014, P = .11).