LC-MS/MS proteome analysis of liver ECs reveals profound metabolic and cytoskeletal changes during initiation of angiogenesis in GVHD. (A) LC-MS/MS proteome analysis of liver ECs at day+2 after BMT (LP/J→C57BL/6) with 1518 proteins, and >24 000 peptides quantified revealed 25 proteins downregulated and 18 upregulated proteins between ALLO and SYN mice (n = 5 per group). (B-C) Table of downregulated and upregulated proteins with corresponding functions/mechanisms and normalized ratios. In supplemental Tables 3 and 4, a detailed list of protein symbols + names, cellular localization, and involved pathways is available. ATP, adenosine triphosphate; GAG, glycosaminoglycans; PAF, platelet activating factor; PPP, pentose phosphate pathway.