The Ampd3^T689A mutation causes an altered response to malaria. Cumulative survival (A) and peripheral parasitemia (B) for female WT (n = 17), Ampd3^T689A/+ (n = 11), and Ampd3^T689A (n = 6) infected with P. chabaudi. (C) Mean ± SEM fold change in parasitemia compared with WT for Ampd3^T689A/+ labeled RBCs. Dotted line indicates equal ratio of WT to mutant. (B) Mean ± SEM proportion of ring stage (thiazole orange^low, Hoechst^low), and trophozoite stage (thiazole orange^high, Hoechst^high) parasites within labeled WT and Ampd3^T689A/+cells (n = 7). *P < .05; **P < .01; ***P < .001. P values calculated using the log-rank test (survival) or the Student t test.