Family pedigrees and bleeding scores in 2 unrelated families carrying novel mutations S381F and R113X in CalDAG-GEFI. The index cases in each family are indicated with black arrows. Bleeding in patients and available family members was evaluated and a bleeding score was assigned by using the International Society on Thrombosis and Haemostasis Bleeding Assessment tool.¹⁶  Filled and partially filled black symbols indicate homozygosis and heterozygosis for the corresponding mutation in RASGRP2. Other family members (white symbols) were not available for study.