Grading of pathologic features seen in iMCD. The following images are examples of the respective grades for each histopathologic feature. Deidentified lymph node slides were obtained prestained with hematoxylin and eosin from Janssen Pharmaceuticals and scanned using an Aperio CS scanner (Leica Biosystems, Wetzlar, Germany) at 20×/0.75NA Plan Apochromat. Images were captured using Aperio Imagescope and enhanced to 300 dpi using Photoshop. Bars represent 500 μm (A,D), 80 μm (B), 200 μm (C), 60 μm (E). (A) Regressed/atrophic germinal centers. (B) Follicular dendritic cell prominence. (C) Vascularity. (D) Hyperplastic germinal centers. (E) Plasmacytosis.