VAV1-GSS fusion drives cytoskeletal reorganization, migration, and proliferation. (A) VAV1-GSS fusion promotes cytoskeletal reorganization and (B) increased cell circularity in adherent NIH-3T3 cells. A circularity value of 1 indicates a perfect circle. (C) The VAV1-GSS fusion protein is phosphorylated at VAV1 Y174 in Jurkat cells. In Jurkat, VAV1-GSS drives cell (D) migration and (E) growth relative to both wild-type VAV1 and an empty vector control.