Figure 1.
Figure 1. Key somatic mutations and growth factor receptors important for MPN development. (A) Simplified “roadmap” of hematopoietic development. (B) Distribution of key growth factor receptors in different stem, progenitor, and precursor cell populations. For each population, potential impact of JAK2V617F, CALR, or MPL mutation is indicated.

Key somatic mutations and growth factor receptors important for MPN development. (A) Simplified “roadmap” of hematopoietic development. (B) Distribution of key growth factor receptors in different stem, progenitor, and precursor cell populations. For each population, potential impact of JAK2V617F, CALR, or MPL mutation is indicated.

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