The structural rearrangement landscape of the PDL locus (9p24.1) as determined by capture sequencing. (A) A circos plot representing translocation (black arcs) and large inversion (gray arcs) partners of CD274 (red) and PDCD1LG2 (blue). Smaller dots denote single reported partners, whereas large dots denote partners that were observed twice within our cohort. Black dots were Sanger validated; red dots were PCR validated only, and gray dots were not validated due to exhaustion of clinical material. (B) A linear plot denoting the location of the translocation breakpoints in the PDL region (arrows) with partners labeled above. Newly annotated CBRs, CBR1 and CBR2, are indicated. Gray shading represents the captured region.