KRK α₁AT reduces bleeding and increases platelet and fibrin deposition in hemophilia B mice. (A) Total blood loss of either wt (gray) or hemophilia B (black) mice injected with either PBS (circles), or KRK α₁AT (squares) after tail clip. Each data point is from a single mouse. Lines show the average per group. P values were calculated by using an unpaired Student t test. (B-C) Median accumulation of (B) platelets and (C) fibrin over time after laser-induced arteriole injury after administration of PBS (black line; 8 total thrombi, 5 mice) or KRK α₁AT (gray-shaded dotted and solid lines; 18 total thrombi, 4 mice at 7.5 mg/kg; 20 total thrombi, 3 mice at 15 mg/kg).