Liver biopsy from patient with acute liver failure after HSCT compared with example cases. (A) Example case, low power image of GVHD (left) with minimal lobular inflammation in contrast to IPI-associated hepatitis (right) showing pronounced lobular hepatitis (original magnification ×50; hematoxylin and eosin stain). (B) Example case, high power view of a portal tract in a patient with GVHD exhibiting cholestasis and bile duct injury, evidenced by cells with nuclear pleomorphism, eosinophilic cytoplasm, and intracytoplasmic vacuoles (original magnification ×400; hematoxylin and eosin stain). (C) Example case, high power image of IPI-associated hepatitis exhibiting a pan-lobular, predominantly lymphocytic infiltrate with spotty hepatocellular necrosis (original magnification ×200; hematoxylin and eosin stain). (D-F) Patient case demonstrating striking centrizonal hemorrhage and hepatocellular dropout as well as bile duct injury. (D) Original magnification ×50; hematoxylin and eosin stain. (E) Original magnification ×400; hematoxylin and eosin stain. (F) Original magnification ×400; hematoxylin and eosin stain.