Figure 2.
Figure 2. Increased enucleation in vivo and in vitro in double-heterozygote fetal liver cells. (A) Peripheral smears with nucleated and enucleated (arrow) erythrocytes from WT, th3/+, and double-heterozygote E14.5 embryos. (B) Flow cytometry analysis of nucleated and enucleated (circles; SYTO ×60 low cells53,54) E18.5 fetal liver cells in vivo. (C) Flow cytometry analysis of nucleated and enucleated (circles; SYTO ×60 low cells53,54) E12.5 to E14.5 WT, th3/+, and double-heterozygote fetal liver cells in vitro (n = 3–5 mice per group). *P < .05 vs WT mice; †P < .05 vs th3/+ mice; ††P < .01 vs th3/+ mice.

Increased enucleation in vivo and in vitro in double-heterozygote fetal liver cells. (A) Peripheral smears with nucleated and enucleated (arrow) erythrocytes from WT, th3/+, and double-heterozygote E14.5 embryos. (B) Flow cytometry analysis of nucleated and enucleated (circles; SYTO ×60 low cells53,54 ) E18.5 fetal liver cells in vivo. (C) Flow cytometry analysis of nucleated and enucleated (circles; SYTO ×60 low cells53,54 ) E12.5 to E14.5 WT, th3/+, and double-heterozygote fetal liver cells in vitro (n = 3–5 mice per group). *P < .05 vs WT mice; †P < .05 vs th3/+ mice; ††P < .01 vs th3/+ mice.

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