Figure 4
Figure 4. MHC class II antigen presentation by donor cDCs is not critical for Teff function in cGVHD. (A) Lethally irradiated B6D2F1 recipients were transplanted with 5 × 106 TCD BM cells from CD11c Creneg or I-Ab CD11c Crepos donor mice with 0.5 × 106 CD3+ T cells from B6.luc+ mice previously depleted in Tregs with the administration of the antibody PC61. (B) Representative images of the B6.luc+ CD3+ T cells are represented in the whole mice at day 23 after BMT. The BLI (ph s−1 cm−2 sr−1) is represented and followed over time every week after BMT (n = 14-15, 3 experiments).

MHC class II antigen presentation by donor cDCs is not critical for Teff function in cGVHD. (A) Lethally irradiated B6D2F1 recipients were transplanted with 5 × 106 TCD BM cells from CD11c Creneg or I-Ab CD11c Crepos donor mice with 0.5 × 106 CD3+ T cells from B6.luc+ mice previously depleted in Tregs with the administration of the antibody PC61. (B) Representative images of the B6.luc+ CD3+ T cells are represented in the whole mice at day 23 after BMT. The BLI (ph s−1 cm−2 sr−1) is represented and followed over time every week after BMT (n = 14-15, 3 experiments).

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