Leukocyte trafficking depends on integrin activation. Leukocytes in flowing blood are captured by and roll via selectin ligand interactions. Selectin engagement signals talin-mediated integrin activation that leads to integrin extension and slowed rolling. Activation of the leukocytes, usually through G-protein–coupled receptors culminates in kindlin and talin-mediated arrest and subsequent leukocyte transmigration. Graphical art has been adapted from Les Laboratoires Servier © 2016.