Figure 1.
Figure 1. Immunoprophylaxis with anti-KEL sera prevents alloimmunization in wild-type, FcγR KO, and C3 KO mice, but not in FcγR KO × C3 KO (double-KO) mice. (A) General experimental design. Recipients were passively immunized with anti-KEL sera in some experiments, followed by transfusion of murine RBCs expressing the human KEL glycoprotein. Alloimmune responses were measured in serum after transfusion. (B) Total anti-KEL IgG measured in the serum of recipients on day 28 posttransfusion. (C) Total anti-KEL IgG measured in the serum of recipients treated with anti-KEL immunoprophylaxis prior to RBC exposure; P < .05 by 1-way ANOVA between double-KO and all other recipients. These data are a compilation of 2 independent experiments with 2 or 3 mice per group per experiment.

Immunoprophylaxis with anti-KEL sera prevents alloimmunization in wild-type, FcγR KO, and C3 KO mice, but not in FcγR KO × C3 KO (double-KO) mice. (A) General experimental design. Recipients were passively immunized with anti-KEL sera in some experiments, followed by transfusion of murine RBCs expressing the human KEL glycoprotein. Alloimmune responses were measured in serum after transfusion. (B) Total anti-KEL IgG measured in the serum of recipients on day 28 posttransfusion. (C) Total anti-KEL IgG measured in the serum of recipients treated with anti-KEL immunoprophylaxis prior to RBC exposure; P < .05 by 1-way ANOVA between double-KO and all other recipients. These data are a compilation of 2 independent experiments with 2 or 3 mice per group per experiment.

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