Rapamycin suppresses age-associated elevation of MPV in mice. (A) Complete blood count analysis of 4- or 16-month-old mice treated with rapamycin (1.5 mg/kg per day) for 2 months. (A) MPV and (B) platelet counts are shown (n = 10). Values represent means ± SEM; *P < .05; **P < .01. (C) Western blot analysis of platelets from mice described in panel A for mTORC1 (P-S6, P-P70S6K) activity.