Figure 2
Figure 2. Deletion of mTORC1 in MKs and platelets reduces susceptibility to venous thrombosis in mice. (A) Western blot analysis of activated or resting platelets from platelet-specific Raptor-deletion (KO) or wild-type (WT) mice for Raptor, P-S6, and P-P70S6K expression. A typical result of platelets from 3 different mice is shown. Images (B), lengths (C), and weights (D) of thrombi that developed in the IVC 48 hours after ligation were measured in 12-month-old WT and Raptor KO mice (n = 6). Values represent mean ± SE. **P < .01.

Deletion of mTORC1 in MKs and platelets reduces susceptibility to venous thrombosis in mice. (A) Western blot analysis of activated or resting platelets from platelet-specific Raptor-deletion (KO) or wild-type (WT) mice for Raptor, P-S6, and P-P70S6K expression. A typical result of platelets from 3 different mice is shown. Images (B), lengths (C), and weights (D) of thrombi that developed in the IVC 48 hours after ligation were measured in 12-month-old WT and Raptor KO mice (n = 6). Values represent mean ± SE. **P < .01.

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