Dichotomized separation of lower- vs higher-risk MDS patients in IPSS-R–stratified patients. Kaplan-Meier curves for (A) overall survival and (B) respective hazards plots for patients with an IPSS-R score of ≤3.5 vs >3.5 points which yields the best results regarding prognostic power. Panels A and B show a good separation of patients with initially higher but declining risk vs patients with constant lower risk. Note differing time scales for the Kaplan-Meier and hazard plots.