Stability of scores in lower-risk patients (Kaplan-Meier curves and hazard plots). Overall survival shown by (A,C) Kaplan-Meier curves and (B,D) hazard plots using (A,B) LR-PSS and (C,D) IPSS-RA. The figure demonstrates that scores applied to lower-risk MDS have lower prognostic power but remain more stable over time and are less affected by the attenuation of subgroup-specific hazards (B,D). This is seen for both the LR-PSS and for the IPSS-RA, with both scores restricted to the IPSS-R very-low-/low-/intermediate-risk patients (panels A and C, survival curves). (C-D) An increase of mortality risk related to age is shown. LR-PSS categories: C1, score 0 to 2; C2, score 3 to 4; C3, score 5 to 7. Note differing time scales for the Kaplan-Meier and hazard plots.