Murine model partially reproduces the human pathology.Mpl knockout lin⁻ cells were transduced with MPL WT or MPL P106L and then injected into lethally irradiated Mpl^−/− mice. (A) Platelets and (B) THPO levels, respectively, were analyzed 1 month after transduction using impedance measure and enzyme-linked immunosorbent assay. At least 2 mice were used to constitute each group, apart from the control group, in 2 different experiments. (C) Schematic model of the mechanism induced by MPL P106L. *P < .05. Filled circles, filled boxes, and filled triangles defined the level for each mouse. ns, nonsignificant.