Efforts to decipher the immune mechanism underlying antibody-mediated suppression of the immune response to human KEL protein in a mouse model. IgG-mediated suppression of the immune response (AMIS) to human KEL protein occurs in the absence of FcγR or C3, but not when both FcγR and C3 are absent. Antigen modulation or clearance is associated with suppression. Professional illustration by Somersault 18:24.