Redundant pattern recognition receptors mediate the prothrombotic effects of HMGB1. (A) Thrombus weight in C57Bl/6 mice (n = 32) compared with Tlr2^−/− mice (n = 12), Tlr4^−/− mice (n = 12), Rage^−/− mice (n = 14), Myd88^−/− mice (n = 12). Lines indicate mean. One-way ANOVA followed by LSD–post hoc test was used to compare results between groups. (B) Thrombus weight in C57Bl/6 mice receiving vehicle (n = 13) compared with anakinra s.c. (n = 8). Lines indicate mean. The Student t test was used to compare results between groups.