Clinical factors are associated with the development of early hepatotoxicity. (A) Significant difference in age at enrollment between subjects who experienced no toxicity on trial and those who experienced early hepatotoxicity (P = .02, Mann-Whitney U test). (B) Receiver-operating characteristic (ROC) curves for mutated (M) IGHV status, age ≤65 years, or a combination of the two for predicting the occurrence of early hepatotoxicity.