Atorvastatin displayed superior effects on the number and function of BM EPCs from PGF subjects compared with GGF subjects or normal controls. The cultivated BM EPCs from PGF or GGF subjects or normal controls were incubated with atorvastatin (500 nM). The effects of atorvastatin treatment on the cell number (A), cell proliferation (B), double positive staining cells (per well) (C), migration (D), tube formation (E), apoptosis (F), and ROS levels (G) of cultivated BM EPCs from PGF or GGF subjects or normal controls were compared at day 7 in culture. (H) CFU plating efficiency in CD34⁺ BM cells was analyzed after coculturing with the differently treated BM EPCs from PGF or GGF subjects or normal controls. The CFU outgrowth was improved with atorvastatin, but the results were not statistically significant. Data are expressed as the fold-change relative to PGF.