Dose-response effects of atorvastatin treatment on the number and function of cultivated BM EPCs from PGF subjects. BM EPCs from PGF subjects were incubated with atorvastatin (0.5 nM, 50 nM, 500 nM). The dose-response effects of atorvastatin treatment on cell number (per well) (A), cell proliferation (B), migration (C), tube formation (D), and ROS levels (E) of cultivated EPCs from PGF subjects were evaluated at day 7 in culture. Data are expressed as fold-change relative to PGF. All of the P values < .05 were considered statistically significant and provided in the panels. The changes were not statistically significant in panels C and D.