IL-1RA in combination with NIL inhibits NF-κB target gene and cytokine gene expression in CML LSC. Expression of the NF-κB target genes, NFKB1A (A), BCL2L1 (B), and BIRC3 (C) and the inflammatory cytokines, IL-1α (D), IL-1β (E), IL-6 (F), CXCL1 (G), CXCL2 (H), CCL2 (I), CCL3 (J), CCL4 (K), and TNF-α (L) in CML CD34⁺CD38⁻CD90⁺ cells treated with IL-1RA, NIL, or the combination of NIL and IL-1RA, was measured by qRT-PCR. Results represent mean ± SEM. Significance values: *P < .05; **P < .01, ***P < .001, paired Student t test.