Many human myeloma cell lines are killed when MCL1 is genetically targeted. A panel of 19 myeloma cell lines was infected with a lentivirus that encodes for sgMCL1 #1 (described in Figure 3) or, as controls, the empty vector (EV). Cell viability was determined using the CellTiter-Glo assay 72 hours after the addition of DOX to induce expression of the sgRNA. A discrete heat map representation of the data is shown: red indicates very strong killing (cell viability reduced to <15%) when expression of the sgRNA is induced. In contrast, blue (>75% cell viability) indicates that the cells tolerated the genetic targeting of MCL1. *Fourteen cell lines in which expression of the sgMCL1 #1 reduced the viability by at least 50%. The results represent the mean values of 3 triplicate wells from a single experiment; the raw data are shown in supplemental Table 5.