Anti–myosin antibody–induced reduction of thrombin peak values observed for acute trauma coagulopathy plasma and normal control plasma following tissue factor/Ca⁺⁺ ion addition. The effects of anti–myosin antibodies on the 0.1-pM TF-induced peak of thrombin generation in plasmas from acute traumatic coagulopathy patients (N = 26) and healthy controls (N = 20) were tested using either polyclonal antiserum against myosin heavy and light chains or nonimmune control antiserum, respectively (2 mg/mL protein). The graphs show the reduction of thrombin peak values by anti-myosin antibodies either as percent of control peak (A) or in absolute concentration of the thrombin peak (B). Bars indicate median values.