Figure 3
Figure 3. Knockdown of miR-139-5p results in the expansion of LSK cells and myeloid progenitors. (A) Flow cytometric analysis of hematopoietic progenitors with CD34 and FcγRIII expression in LK population (Lin−c-Kit+Sca-1−) (left). Average frequency of CMP (CD34hiFcγRIII+), GMP (CD34+FcγRIIIhi), and MEP (CD34−FcγRIII−) in LK subsets is depicted (right). (B) Representative flow cytometric profiles of LSK (Lin−c-Kit+Sca-1+) and LK (Lin−c-Kit+Sca-1−) subpopulations (left) and average frequency of LSK subsets in reconstituted mice (right).

Knockdown of miR-139-5p results in the expansion of LSK cells and myeloid progenitors. (A) Flow cytometric analysis of hematopoietic progenitors with CD34 and FcγRIII expression in LK population (Linc-Kit+Sca-1) (left). Average frequency of CMP (CD34hiFcγRIII+), GMP (CD34+FcγRIIIhi), and MEP (CD34FcγRIII) in LK subsets is depicted (right). (B) Representative flow cytometric profiles of LSK (Linc-Kit+Sca-1+) and LK (Linc-Kit+Sca-1) subpopulations (left) and average frequency of LSK subsets in reconstituted mice (right).

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