Results from zebrafish model demonstrate that VEGFB, PlGF, and VEGFD can compensate for the lack of VEGFA and solidify roles of individual VEGFRs in vivo, thereby opening new directions in treatment of human pathologies associated with vascularization. The inset has been adapted from Figure 1F in the article by Rossi et al that begins on page 2359, and shows confocal micrographs of 48-hpf TgBAC(etv2:EGFP) WT siblings and vegfaabns1 mutant zebrafish embryos in lateral view. Asterisks denote lack of ISVs, DA, and reduced CtA sprouting. CtA, central artery; DA, dorsal aorta; hpf, hours postfertilization; ISV, intersegmental vessel; PCV, posterior cardinal vein. Professional illustration by Patrick Lane, ScEYEnce Studios.