Vessel ECM abnormality contributes to the bleeding diathesis in TSP2 KO mice. (A) Rescue of irradiated WT and KO mice with KO and WT bone marrow cells, respectively, did not alter the bleeding time of the host. In addition, homotypic rescue maintained the original phenotype. Transplant of WT bone marrow to irradiated TSP2 KO mice did not reduce the bleeding time. Circles (●) denote individual mice. (B-C) Representative SEM images of denuded carotid arteries from WT mice receiving TSP2 KO bone marrow (B) and TSP2 KO mice receiving WT bone marrow (C) 10 minutes after wire injury. (D) Quantification of thrombus size by ImageJ revealed a decrease in TSP2 KO arteries. *P < .05