BCR score predicts for PFS and OS in MCL. Probabilities of PFS and OS were compared in subgroups dichotomized by BCR score measured in the LN samples using the log-rank test. The median OS or PFS time was calculated as the smallest survival time when the survival probability is ≤50%. (A) The median PFS time for patients with BCR score within the upper tercile was 2.0 years and was 2.9 years for the remaining patients. (B) At the median follow-up of 7.5 years, the estimated OS for patients with BCR score in the upper tercile was 68% and was 96% for the remaining patients. The median OS time for patients dichotomized by BCR score was (C) in an independent validation set 1.5 years and 3.2 years, respectively, and (D) in both sets combined (n = 126) 3.1 and 5.5 years, respectively.