Aberrant erythrocyte morphology. (A-C) Wright-Giemsa stain of peripheral blood smears from 3-week-old mice. Shown at ×60 original magnification. (D-I) Scanning electron microscopy of peripheral blood cells of 18-week-old mice. Shown at ×4000 original magnification. Blue arrows show spherocytes; red arrows show extensive microcytic vesiculation and protruding structures; and green arrows show many invaginations in FLKO erythrocytes/reticulocytes. (I) An enlarged view of the rectangle area shown in H to highlight the presence of multiple invaginations in a single cell. (^+/+), WT; (^+/−), heterozygous; (^−/−), dematin FLKO.