Aberrations affecting tumor-suppressor genes. Deletions and nonsilent mutations for 10 selected tumor-suppressor genes with a potential impact on MM pathogenesis.^17,20  Mutations and copy number profiles were derived from whole-exome sequencing and high-resolution copy number arrays, respectively. Samples without high-resolution copy number data were excluded from the analysis but are shown as not available in the plot. The risk status was determined using the classical GEP70 classifier.