Pharmacokinetic studies of ONO/GS-4059. Plasma concentration-time profiles of ONO/GS-4059 on day 1 (A) and day 28 (B) after once-daily oral administration. Graphs show the mean plasma concentration of ONO/GS-4059 (ng/mL) for all patients in both CLL and NHL cohorts according to dose cohort. Error bars represent the standard deviation.