Efficacy of ONO/GS-4059 in patients with MCL. (A) Waterfall plot for all MCL patients by dose cohort (n = 12), showing response evaluated by CT imaging. Changes from baseline scan (sum of the largest diameter of each target lesion) are shown. Negative values indicate tumor response. (B) Duration on treatment for all MCL patients (n = 16) according to dose cohort. *Ongoing patients.