Biological significance and clinical relevance of TCR signaling–related mutations. (A) Spider plot representation of gene sets differentially enriched in patients with or without mutations in genes related to TCR signaling (TCR_Mut vs TCR_WT). Genes tested in the enrichment analysis were selected from signatures relevant in T- and B-cell differentiation and activation. Statistical significance of the enrichment was reached for gene sets 1 to 15 (P < .05); for gene set 16, marginal significance was observed (P = .1). (B-C) Overall survival (B) and progression-free survival (C) of patients with (red) or without (blue) mutations in TCR signaling–related genes. Analyses are restricted to the 59 patients treated with anthracyclin-based chemotherapy. Mutated patients show a trend toward a shorter PFS (11 vs 36 months) than WT patients (P = .15).