Mutual exclusivity of TCR signaling variants. The mutational status of TCR-related genes is represented for the 85 patients of the extended cohort. Genes other than RHOA are ranked by decreasing mutation frequency and show an essentially mutually exclusive mutation pattern. In total, 49% of cases were mutated in 1 or several TCR-related gene(s) other than RHOA (hereafter considered as TCR_Mut), 28.5% were mutated in RHOA only, and 22.5% harbored no mutation in any of the genes tested (collectively considered as TCR_WT).