Kaplan-Meier estimates of PFS and OS in doublet regimens with no alkylating agents vs triplet regimens with alkylating agents after a median follow-up of 39 months. (A) Median PFS was 21 months in doublet regimens with no alkylating agents vs 22 months in triplet regimens with alkylating agents. (B) Four-year OS was 58% in the doublet regimens with no alkylating agents vs 67% in the triplet regimens with alkylating agents.