This demonstrates the sequential role of VWF in the process of central nervous system (CNS) malaria. Endothelial cells are activated and release VWF from the Weibel Palade bodies into circulating blood, platelets adhere, parasite-infected red blood cells (RBCs) are recruited, and VWF induces increased endothelial cell permeability and leads to CNS thrombosis. EC, endothelial cell; WP, Weibel Palade. The figure has been adapted from Figure 6 in the article by O’Regan et al that begins on page 1192.