MyD88 is required for the development of FHL2 in mice.Prf1^−/− mice (n = 3) and Prf1^−/−Myd88^−/− mice (n = 3) were infected with LCMV and analyzed 10 days postinfection for signs of FHL2. Representative of 3 independent experiments. Analyzed by Student 2-tailed t test. (A) Spleen weight expressed as a ratio of total body weight. (B) Platelet counts and hemoglobin levels from peripheral blood. (C) Representative hematoxylin and eosin–stained liver sections, original magnification ×100. (D) Serum IFNγ levels. (E) Frequencies of splenic LCMV-specific T cells stained with gp33 major histocompatibility complex class I tetramer (tetr). *P < .05; ***P < .001.