Figure 3
Figure 3. Correlations between in vivo venetoclax sensitivity and basal BCL-2/BCL-XL expression or in vitro venetoclax responses. (A-F) Basal protein or mRNA expression of BCL-XL, BCL-2, or the ratio of BCL-2:BCL-XL is plotted against leukemia growth delay (T − C). With Bonferroni correction for multiple comparisons (n = 8), P < .00625 for statistical significance. Each data point represents 1 xenograft. (G-H) In vitro LC50 values by AlamarBlue or coculture assays are plotted against leukemia growth delay (T − C). With Bonferroni correction for multiple comparisons (n = 2), P < .025 for statistical significance.

Correlations between in vivo venetoclax sensitivity and basal BCL-2/BCL-XL expression or in vitro venetoclax responses. (A-F) Basal protein or mRNA expression of BCL-XL, BCL-2, or the ratio of BCL-2:BCL-XL is plotted against leukemia growth delay (T − C). With Bonferroni correction for multiple comparisons (n = 8), P < .00625 for statistical significance. Each data point represents 1 xenograft. (G-H) In vitro LC50 values by AlamarBlue or coculture assays are plotted against leukemia growth delay (T − C). With Bonferroni correction for multiple comparisons (n = 2), P < .025 for statistical significance.

Close Modal
This Feature Is Available To Subscribers Only

or Create an Account

Close Modal
Close Modal