Changes in circulating T cells after rhIL-7 treatment. Fold change in (A) CD4 T cells and (C) CD8 T cells in the weeks after rhIL-7 administration. Each patient’s results are depicted by a color according to dose (orange, 3 µg/kg; green, 10 µg/kg; blue, 20 µg/kg) and by a unique symbol. The bold black line represents the median value for all patients. Absolute numbers of (B) CD4 T cells and (D) CD8 T cells in each patient over the first 24 weeks of the study using the same color code and symptoms as for (A). (E) Increase in CD4 T cells at week 5 (peak CD4 T-cell count) on the x-axis compared with week 1 (baseline) CD4 T-cell count on the y-axis. Each symbol represents an individual patient using the same color scheme and symbols as in (A). *P < .05; **P < .01.