Hemostatic and immunologic markers in FVII-G96E dogs expressing cFVII following AAV administration. Fibrinogen (A), d-dimer (B), and platelet counts (C) were monitored throughout the study, before and after AAV administration (black arrow, day 0). A shaded box indicates the normal range of values for each marker. All d-dimer levels were within normal range. (D) Anti-cFVII IgG2 levels were determined in all FVII-G96E dogs that received AAV8-cFVII. IgG2 levels are depicted following background correction (for each dog). The following symbols are used for the FVII-G96E dogs (in all panels): closed squares (N24, 4.95E13 vg/kg), open circles (N22, 2E12 vg/kg), closed circles (N25, 6E11 vg/kg), and closed rhombi (Otis, 2E11 vg/kg).