BCR stimulation of CLL cells enhances global and MYC-specific mRNA translation. In the LN, BCR antigen (Ag) stimulation leads to kinase phosphorylation (P) of kinases (Lck/Yes novel tyrosine kinase [LYN], SYK, and BTK), which can be blocked by specific drugs. This results in increased transcription of MYC and translation initiation factors eIF4GI and eIF4A, which further amplify mRNA translation. Activations (green arrows), inhibitions (red lines), and indirect effects (dotted lines) are shown.