NE and EPI administration elevate platelet levels in vivo. (A-B) Changes in the peripheral platelet levels in normal C57BL/6 mice injected with saline, NE, or EPI once a day for 7 days. (C) Distributions of MKs in the BM (H&E staining) in the mice. Arrows point to the pseudopods of MKs (proplatelets) inserting into the vascular sinusoids. (D) Quantification of MKs in the BM in the mice. (E) Quantification of the distance between MKs and the vascular sinusoids in the BM. (F) Experimental schematic of NE and EPI administration in C57BL/6 mice subjected to irradiation. (G) Changes in the peripheral platelet counts in irradiated mice receiving NE or EPI treatment. (H) Time (days) needed for 50% recovery of platelet loss from the nadir in irradiated mice receiving NE or EPI treatment. (I) Experimental schematic of NE and EPI administration in C57BL/6 mice that received BMT after irradiation. (J) Changes in the peripheral platelet counts in grafted mice that received NE or EPI treatment. (K) Time (days) needed for 50% recovery of platelet loss from the nadir in grafted mice receiving NE or EPI treatment. *P < .05, **P < .01, vs control. Each group contains 6 to 7 mice.