Suggested treatment protocol for recurrent DVT.^aApixaban 10 mg twice daily for 1 week followed by 5 mg twice daily, reduce dose to 2.5 mg twice daily after 6 months; rivaroxaban 15 mg twice daily for 3 weeks followed by 20 mg once daily; LMWH once or twice daily at therapeutic dose for at least 5 days followed by 150 mg dabigatran twice daily or by 60 mg edoxaban once daily; ^bLMWH once or twice daily at therapeutic dose together with a VKA (target INR, 2.0-3.0) and continue LMWH until a stable INR has been reached, but for a minimum of 5 days; ^cLMWH at therapeutic dose until 24 hours before induction of labor or caesarean section, and restart LMWH at a reduced dose; ^dLMWH at therapeutic dose, reduced to about 75% at 4 weeks for at least 6 months or as long as it is safe to do so; ^etransient risk factors include surgery, trauma, prolonged bed rest, oral contraceptives, hormone replacement therapy, pregnancy/puerperium; and ^fpersistent risk factors include inflammatory bowel disease, antiphospholipid syndrome, nephrotic syndrome, paroxysmal nocturnal hemoglobinuria, myeloproliferative neoplasma, Behçet syndrome, postthrombotic syndrome, and congenital venous malformation.