Genomic landscape in ALL, AML, MDS, NHL, and MM. Observed frequencies of most mutated genes in (A) ALL, (B) AML, (C) MDS, (D) NHL, and (E) MM. Mutation frequency is grouped by function effect, substitution/indel (red), focal amplification (steel blue), homozygous deletion (peach), rearrangement/fusion (lime green), and truncation (purple). The numbers of cases included in this analysis are 102 cases in ALL, 274 cases in AML, 130 cases in MDS, 297 cases in NHL, and 753 cases in MM. In The clinical relevance including therapeutic (green), clinical trial (olive), prognostic (lavender), and diagnostic (blue) are highlighted on top of each gene.